I dont like the layout and iTunes functionality. I guess it comes down to what youre used to. I like to have all my music grouped by album and folder etc. iTunes when I last used it was all about creating playlists etc. I never use playlists as I just listen to whole albums.
Im guessing its probably possible to make itunes and WMP11 work in exactly the same way so the point is moot. However itd be nice to not have to play around with things to get it to work properly?
Then sort albums, create album playlists or if you use folders then just open up the album folder and play your songs. It is no different to anything else in this sense at all but as sam said you can get an ipod and use other software and still sync etc.